Preheat oven to 350 and butter a 3 to 4 quart (9 x 13) Pyrex or shallow baking dish.
In heavy saucepan, melt 6 T. butter over med-low heat. Add flour and whisk for 3 minutes (creates a roux). Add milk in a stream, whisking, and bring to a boil, whisking. Add mustard, cayenne, salt and pepper, and simmer, whisking, until thickened, approximately 2 minutes.
Cook pasta for 6 minutes in gently boiling water, until just about done (al dente). Drain pasta in colander and in a large bowl gently combine pasta, sauce, Cheddar cheese, 1 cup Parmesan, and sour cream. Transfer to baking dish.
In a small bowl, combine bread crumbs and remaining 1/3 cup Parmesan and sprinkle over pasta. Cut up the remaining 1 T. butter and top bread crumbs.
Bake pasta in middle of oven for 25-30 minutes until golden and bubbling.
To prepare ahead: Keep dish covered in fridge one day ahead, and let it come to room temp before baking.